Extract of Celosia leptostachya Leaves Inhibits Cobra Venom Toxins

Background: Celosia leptostachya belongs to Amaranthaceae plant family. Its leaves are used traditionally in the treatment of conditions, such as convulsion, eye infection and most notably cure snakebites. This study investigated inhibiting effect extract C. against cobra snake venom mice. Methods: We 36 albino mice mixed gender, weighing 20-25 g. They were divided into six groups rats each. Each rat was pre-treated with 0.4 mg/kg venom, subsequently given a graded dose zero, 50, 100, 150, 200, or 250 ethanol leaves. The animals monitored for survival rate. Various inhibition assays performed estimate activities acetyl cholinesterase, protease adenosine triphosphatase presence 100-300 µg extract. Results: inhibited effects significantly after intraperitoneal injection at 20 minutes intervals. results demonstrated that 100% survived if they received 100-250 while only 83.3% 50 mg/kg. venom’s triphosphatase. occurred higher percentages 300 Conclusion: its mediated toxicity.